Activation of PI3K-AKT-mTOR signal pathway in Burkitt lymphoma
10.3760/cma.j.issn.1009-9921.2016.08.003
- VernacularTitle:PI3K-AKT-mTOR信号通路在伯基特淋巴瘤中的活化
- Author:
Chuntuan LI
;
Yifeng CHEN
;
Yan ZHENG
;
Yuanling HUANG
;
Xin MA
;
Xiongpeng ZHU
- Publication Type:Journal Article
- Keywords:
Burkitt lymphoma;
PI3K-AKT-mTOR;
Signal pathway
- From:
Journal of Leukemia & Lymphoma
2016;25(8):457-460
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the activation of PI3K-AKT-mTOR signal pathway in Burkitt lymphoma.Methods The phosphorylation levels of AKT,mTOR and RPS6 were detected in the tissue sections by immunohistochemistry in 13 cases of Burkitt lymphomas and 14 cases of reactive hyperplasia of lymph nodes.Results The phosphorylation rates of AKT,mTOR and RPS6 were higher in Burkitt lymphoma than those in reactive hyperplasia of lymph nodes [84.6 ％(11/13) vs 64.2 ％(9/14),100.0 ％(13/13) vs 71.4 ％ (10/14),100.0 ％ (13/13) vs 78.6 ％ (11/14),all P ＜0.05].Conclusion PI3K-AKT-mTOR pathway is abnormally activated in Burkitt lymphoma.
