Progress on the diagnosis, treatment, and family management of Lynch syndrome
10.3969/j.issn.1000-8179.2016.20.750
- VernacularTitle:Lynch综合征的诊治进展和家系管理
- Author:
Chenhan ZHONG
;
Xiaofen LI
;
Dong XU
;
Ying YUAN
- Publication Type:Journal Article
- Keywords:
hereditary colorectal cancer;
Lynch syndrome;
mismatch repair gene;
microsatellite instability;
screening
- From:
Chinese Journal of Clinical Oncology
2016;43(20):883-886
- CountryChina
- Language:Chinese
-
Abstract:
Lynch syndrome is the most common type of genetically determined colon-cancer predisposition syndrome, accounting for 5%of all colorectal cancer (CRC) cases. This hereditary syndrome is characterized by the germline mutation of human mismatch repair genes and microsatellite instability. Recent studies have shown that Lynch syndrome and sporadic CRC differ in diagnosis and treat-ment;these results are especially relevant for the clinical management of Lynch syndrome. In this review, we reverted to the original characterization of Lynch syndrome, and the developments in its screening and diagnosis were summarized. Furthermore, the manage-ment of families with this disorder was discussed.
