A preliminary study of efficacy of preoperative concurrent chemoradiotherapy for locally advanced gastric cancer
10.3760/cma.j.issn.1004-4221.2016.11.013
- VernacularTitle:局部晚期胃癌术前同步放化疗作用的初步探讨
- Author:
Xin WANG
;
Dongbing ZHAO
;
Jing JIN
;
Lin YANG
;
Yuan TANG
;
Hua REN
;
Ning LI
;
Wenyang LIU
;
Hui FANG
;
Shulian WANG
;
Weihu WANG
;
Yongwen SONG
;
Yueping LIU
;
Yexiong LI
- Publication Type:Journal Article
- Keywords:
Gastric neoplasms/surgery;
Gastric neoplasms/radiotherapy;
Gastric neoplasms/chemotherapy
- From:
Chinese Journal of Radiation Oncology
2016;25(11):1204-1208
- CountryChina
- Language:Chinese
-
Abstract:
Objective The aim of this study was to investigate whether the addition of neoadjuvant chemoradiotherapy ( NACRT ) to surgery can improve outcomes better than neoadjuvant chemotherapy in terms of rate of R0 resection, pathological complete response ( pCR ) and side effects. Methods This exploratory study included primary gastric adenocarcinoma patients staged as clinical T4N0 or anyTN1-3. Intensity modulated radiotherapy was delivered of 40 to 50 Gy in 22 to 25 fractions,5 days/week.Concurrent chemotherapy regimens included S-1 or Capecitabine or a combination of Paclitaxel plus Carboplatin.Results Eleven eligible patients were enrolled. R0 and R2 resections were performed in 9 ( 9/11) and 1 patients, respectively.Peritoneal metastasis was found in 1 case during exploratory laparotomy.The pCR was observed in 1 patient with R0 resection ( 1/10 ) . Ten cases completed radiotherapy and 8 cases completed chemotherapy. Nausea ( 3/11 ) , vomit ( 2/11 ) and anorexia ( 2/11 ) were the most common Grade 3 toxicities. Conclusions NACRT showed an acceptable toxicity and promising activity in locally advanced gastric adenocarcinoma.
