Chemotherapy drug resistance mechanisms of hepatocellular carcinoma to arsenic trioxide
10.3760/cma.j.issn.1673-422X.2016.11.016
- VernacularTitle:肝细胞癌对三氧化二砷的化疗耐药性机制
- Author:
Yaoting CHEN
;
Xiaojun HU
;
Dan LI
;
Hong SHAN
- Publication Type:Journal Article
- Keywords:
Liver neoplasms;
Arsenicals;
Drug resistance,neoplasm;
Molecular targeted therapy
- From:
Journal of International Oncology
2016;43(11):861-864
- CountryChina
- Language:Chinese
-
Abstract:
Many studies have proven that arsenic trioxide (As2 O3 )as a single agent is not effective against hepatocellular carcinoma (HCC).Many scholars believe that chemotherapy drug resistance of HCC to As2 O3 is the most important reason.The underlying drug resistance mechanism of HCC cells to As2 O3 remains unclear.Studies show that potential mechanism may be tightly associated with As2 O3 pharmacokinetics and properties of HCC tissues and complex molecular biology.
