Efficacy of oxcarbazepine monotherapy on adult patients with temporal lobe epilepsy
10.3760/cma.j.jssn.1673-4904.2016.11.009
- VernacularTitle:成年人颞叶癫痫术后奥卡西平单药治疗的效果观察
- Author:
Yong GAO
- Publication Type:Journal Article
- Keywords:
Epilepsy,temporal lobe;
Adult;
Comparative effectiveness research;
Oxcarbazepine;
Carbamazepine
- From:
Chinese Journal of Postgraduates of Medicine
2016;39(11):992-994
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the efficacy of oxcarbazepine monotherapy on adult patients with temporal lobe epilepsy (TLE). Methods Eighty-nine patients with TLE who were admitted to hospital from July 2011 to December 2014 were enrolled in this study. They had underwent surgery. Depending on the postoperative treatment they were divided into oxcarbazepine group (46 patients) and carbamazepine group (43 patients) group. They were treated by oxcarbazepine and carbamazepine after operation. The efficacy and complication were compared. Results The patients in two groups were followed up for 1.5 years. According to Engel grade, the number ofⅠ, Ⅱ, Ⅲand Ⅳ grade in oxcarbazepine group was 29, 10, 5 and 2 patients, in carbamazepine group was 26, 9, 5 and 3 patients, and there was no significant difference (P>0.05). The rate of adverse effect in oxcarbazepine group was 6.5%(3/46), in carbamazepine group was 20.9%(9/43), and there was significant difference (P<0.05). At the end of follow-up, the scores of generic quality of life inventory (GQOLI-74) in oxcarbazepine group was (74.6 ± 2.9) scores, in carbamazepine group was (65.1 ± 3.2) scores, and there was significant difference (t=9.838, P=0.000). Conclusions The efficacy of oxcarbazepine and carbamazepine shows no significant difference in adult TLE.But oxcarbazepine monotherapy has fewer adverse effects and more security.
