Effect of GTA/AVC double inhibitors on C6 brain nerve glima cells
10.3969/j.issn.1005-1678.2016.09.008
- VernacularTitle:GTA／AVC双重抑制剂对C6脑神经胶质瘤细胞作用的影响
- Author:
Jiye REN
;
Hong QIN
;
Jixiang REN
- Publication Type:Journal Article
- Keywords:
GTA/GVA double inhibitor;
C6 brain nerve glima cells;
flow cytometry
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(9):36-38
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of GTA/AVC dual inhibitors on C6 brain nerve glima cells.Methods MTT method was used to test the brain glioma cells activity of proliferation at different times(12 h,48 h,72 h), and using the flow cytometry to detect the change of cells cycle.Results It has obvious inhibitory effcets on C6 brain nerve glima cells, and it was the most obvious at 48 h.GTA/AVC dual inhibitor(2000 μg/mL) treatment group remarkbly rise the G0/G1 rate of celluar, S-phase cell ratio descend, and the cells apoptosis rate was markedly increased.Compared with the control group and the GTA/AVC dual inhibition (1000 μL/mL)treatment group , were significant difference(P<0.05).Conclusion regulating cells cycle progression.
