Hypoglycemic and antioxidant effects of jaceosidin in streptozotocin-induced diabetic mice.
10.4163/jnh.2014.47.5.313
- Author:
Eunkyo PARK
1
;
Byoung Mog KWON
;
In Kyung JUNG
;
Jung Hyun KIM
Author Information
1. Department of Home Economics, Graduate School, Chung-Ang University, Seoul 156-756, Korea.
- Publication Type:Original Article
- Keywords:
jaceosidin;
diabetes mellitus;
antioxidant;
lipid peroxidation
- MeSH:
Animals;
Antioxidants*;
Blood Glucose;
Body Weight;
Catalase;
Diabetes Mellitus;
Diet;
Fasting;
Glucose Tolerance Test;
Hyperglycemia;
Insulin;
Insulin Resistance;
Lipid Peroxidation;
Mice*;
Organ Size;
Streptozocin
- From:Journal of Nutrition and Health
2014;47(5):313-320
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: In this study, we investigated the effects of jaceosidin on blood glucose regulation in type 1 diabetic mice. METHODS: C57BL/6 mice were divided into four groups; normal control (Normal), diabetes control (D-Control), diabetes low-jaceosidin (D-0.005%), and diabetes high-jaceosidin (D-0.02%). Type 1 diabetes was induced by streptozotocin and mice were then fed a diet containing jaceosidin for eight weeks. Fasting blood glucose, oral glucose tolerance test, insulin tolerance test, lipid peroxidation, and antioxidant enzyme activities were assessed. RESULTS: Jaceosidin supplementation for eight weeks had no effect on body weight, organ weight, and blood lipid profiles. However, jaceosidin supplementation significantly lowered fasting blood glucose level and reduced insulin resistance. We also found that jaceosidin supplementation increased antioxidant capacity by enhancement of catalase and GSH-px activities. CONCLUSION: These results suggest that jaceosidin could be a therapeutic candidate to ameliorate hyperglycemia through increase of antioxidant enzyme activity.
