Prognosis and risk factors of antineutrophil cytoplasmic antibody-associated vasculitis patients on maintaining dialysis
10.3760/cma.j.issn.1001-7097.2016.10.003
- VernacularTitle:抗中性粒细胞胞质抗体相关性小血管炎维持性透析患者的预后及危险因素分析
- Author:
Lin ZHENG
;
Fei HAN
;
Xishao XIE
;
Liangliang CHEN
;
Yanhong MA
;
Ying XU
;
Xiaohui ZHANG
;
Jianghua CHEN
- Publication Type:Journal Article
- Keywords:
Antibodies,antineutrophil cytoplasmic;
Vasculitis;
Peritoneal dialysis;
Renal dialysis;
Survival rate
- From:
Chinese Journal of Nephrology
2016;32(10):734-738
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the prognosis and risk factors for antineutrophil cytoplasmic antibody?associated vasculitis (AAV) patients on maintaining dialysis. Methods AAV patients on maintaining peritoneal dialysis (PD) or hemodialysis (HD) in First Affiliated Hospital Zhejiang University from June 2007 to June 2015 were included, and were followed up until death, kidney transplant, changed dialysis modalities or January 31, 2016. Patients were divided into PD group and HD group for comparison. Their survival rates and risk factors were analyzed by Kaplan?Meier analysis and COX regression model respectively. Results A total of 123 cases were chosen, with a median duration of dialysis for 854 (388, 1573) days, and with 88 cases (71.5%) on HD and 35 cases (28.5%) on PD. Fifty?two patients (42.3%) were more than 65 years old. At the median follow?up time of 36 months, 39 patients (31.7%) died. The main causes of death were cardiovascular events (30.8%) and infection (23.1%). COX regression analysis showed that patients older than 65 years old (HR=3.289, P=0.001), with cardiovascular disease (HR=3.241, P=0.003) and interstitial pneumonia (HR=2.173, P=0.048) at the dialysis onset were independent risk factors affecting survival. Conclusions Factors including age (older than 65 years), pre?dialysis cardiovascular disease and interstitial pneumonia were independent risk factors affecting survival of AAV patients on maintaining dialysis, then infections and cardiovascular events were the main causes of death.
