Impact of molecular subtype classification on personalized radiotherapy for breast cancer
10.3760/cma.j.issn.1004-4221.2016.11.028
- VernacularTitle:分子分型指导下的乳腺癌个体化放疗
- Author:
Lu CAO
;
Jiayi CHEN
;
Cheng XU
- Publication Type:Journal Article
- Keywords:
Molecular subtype;
Breast neoplasms/radiotherapy;
Radiotherapy,adjuvant
- From:
Chinese Journal of Radiation Oncology
2016;25(11):1272-1276
- CountryChina
- Language:Chinese
-
Abstract:
As a milestone in the development of personalized comprehensive treatment for breast cancer, molecular subtype classification quantitatively characterizes breast cancer as heterogeneous diseases rather than a single disease in terms of onset risk, natural course, and treatment response. The significance of molecular subtype classification has been widely confirmed in prediction of the efficacy of systemic treatment and prognosis of systemic metastases and risk of death. However, the association between molecular subtype and local?regional recurrence ( LRR) risk as well as the impact of molecular subtype classification on radiotherapy strategy still needs more attention. This review discusses the association between molecular subtype and LRR risk as well as the significance of molecular subtype classification in guiding radiotherapy strategy.
