Relationship bewteen gastric pH and hospital-acquired pneumonia in neurological intensive care unit patients
10.3760/cma.j.issn.1006-7876.2016.11.008
- VernacularTitle:神经重症患者胃液 pH 值监测与医院获得性肺炎的相关性
- Author:
Chen MA
;
Jingya WEI
;
Bo HUI
;
Jiwen ZHU
;
Xin ZHENG
;
Tao KANG
;
Xiaogang KANG
;
Fang YANG
;
Wen JIANG
- Publication Type:Journal Article
- Keywords:
Intensive care units;
Hospitals;
Pneumonia;
Gastric juice
- From:
Chinese Journal of Neurology
2016;49(11):864-868
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between gastric juice pH and hospital-acquired pneumonia ( HAP) , the gastric bacterial colonization and etiology of HAP in neurologic intensive care unit patients by monitoring gastric juice pH value.Methods From October 2014 to May 2015, consecutive seventy-two tube feeding patients admitted in the Department of Neurology Intensive Care Unit in Xijing Hospital were enrolled in this research.The type and concentration of pathogens from gastric contents were collected, while samples from upper respiratory tract and pharynx were detected dynamically at the same time.Results (1)The group with new onset HAP was higher in gastric juice pH (6.4(5.4,6.4) vs 5.4 (2.5, 6.4), Z=-2.37, P=0.01); (2) The isolation rate of colonized bacteria in gastric cavity was associated with the pH of gastric juice , achieving 60.8% ( 42/69 ) in HAP group; ( 3 ) When the gastric juice pH was >4, the isolation rate of Gram-negative bacilli in gastric cavity obviously increased (63.6%(28/44) vs 35.7%(10/28),χ2 =5.323, P=0.021); (4)The same pathogens were found in stomach-pharynx-upper respiratory tract in 7 cases ( 17.5%) of the total 40 HAP patients.Conclusion Increased gastric juice pH was associated with gastric colonization , especially Gram-negative bacilli , and may lead to a higher incidence of new onset HAP in patients on enteral feeding.
