Clinical value of tuberculosis protein chip in the diagnosis of tuberculosis infection
10.3760/cma.j.issn.1009-9158.2016.10.012
- VernacularTitle:结核蛋白芯片法检测结核分枝杆菌的临床评价
- Author:
Ke WANG
;
Hongying DAI
;
Yin ZHANG
;
Yanzi ZHANG
;
Tianjin ZHU
;
Zhigui TANG
;
Yongqiang. YUAN
- Publication Type:Journal Article
- Keywords:
Mycobacterium tuberculosis;
Protein array analysis;
Tuberculosis,pulmonary;
Evaluation studies
- From:
Chinese Journal of Laboratory Medicine
2016;39(10):776-778
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the Mycobacterium tuberculosis infection status and Clinical Characteristics in Yongchuan District, Chongqing by Tuberculosis Protein Chip.Methods Compared the conventional method to detect Mycobacterium tuberculosis in infectious department outpatient of Yongchuan Hospital , Chongqing Medical University from July 2014 to June 2015.Tuberculosis protein chip was selected to detect the Mycobacterium tuberculosis infection in Yongchuan area.Chi-square Test was applied to analyze the results.Results The positive rate of Tuberculosis Protein Chip, T-SPOT.BT, DNA Chip, Golden immnnochromatog-raphy, Acid-fast staining were 81.5%, 90.7%, 89.5%, 63.5% and 38.3%respectively on 162 cases of Pulmonary tuberculosis.The five methods were considered significant difference on the diagnosis of Pulmonary tuberculosis ( P<0.05 ).The positive rate of Tuberculosis Protein Chip, T-SPOT, Golden immnnochromatog-raphy were 90.6%,T-SPOT 94.3%and 47.2% respectively on 53 cases of extrapulmonary tuberculosis, it was a significant difference with the three methods(P<0.05),but there was no significant difference with Tuberculosis Protein Chip and T-SPOT.BT ( P>0.05 ).The highest positive rates of anti-LAM was 94%.Conclusion The results of Tuberculosis protein chip are reliable on pulmonary tuberculosis and extrapulmonary tuberculosis diagnosis.
