Research Progress on Gene Alterations of Amelogenin Locus in Gender Identification

VernacularTitle:性别鉴定中amelogenin基因座变异的研究进展
Author: Jiangping HUANG ; Fan YANG ; Yanan LIU ; Kainan ZOU ; Yu CAO ; Dan WU ; Ronghua CHEN ; Yuan PING ; Huaigu ZHOU
Publication Type:Journal Article
Keywords: forensic genetics; amelogenin; review; gender identification; mutation
From: Journal of Forensic Medicine 2016;32(5):371-377
CountryChina
Language:Chinese
Abstract: There are two kinds ofamelogeningene mutation, including mutation in primer-binding re-gion ofamelogeningene and micro deletion of Y chromosome encompassingamelogeningene, and the latter is more common. The mechanisms of mutation in primer-binding region ofamelogeningene is nu-cleotide point mutation and the mechanism of micro deletion of Y chromosome encompassingamelo-geningene maybe non-allelic homologous recombination or non-homologous end-joining. Among the population worldwide, there is a notably higher frequency ofamelogeningene mutations in Indian popu-lation, Sri Lanka population and Nepalese population which reside within the Indian subcontinent. Thoughamelogeningene mutations have little impact on fertility and phenotype, they might cause incor-rect result in gender identification. Using composite-amplification kit which including autosomal STR lo-cus,amelogeningene locus and multiple Y-STR locus, could avoid wrong gender identification caused byamelogeningene mutation.