Expression and clinical significance of NrF-2 and Ho-1 in gastric carcinoma
10.3969/j.issn.1005-1678.2016.09.042
- VernacularTitle:胃癌组织中NrF-2和Ho-1的表达及临床意义
- Author:
Yang SONG
;
Yanping HU
;
Rui WANG
- Publication Type:Journal Article
- Keywords:
gastric cancer tissue;
nuclear factor E-2 related factor 2;
heme synthase -1
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(9):146-148
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study nuclear factor E-2 related factor 2(NrF-2) and heme oxygenase -1(Ho-1) expression and to explore its clinical significance.Methods From February 2016 to June 2016, 176 cases human gastric tissue paraffin blocks selected in department of pathology in Hangzhou Cancer Hospital, including 78 cases of gastric cancer, 78 cases of normal tissue were analyzed.And the expressions of NrF-2 and Ho-1 were detected by immunohistochemistry in two groups of human gastric tissue.Results The levels of NrF-2 and Ho-1 in gastric cancer group were(0.752 ± 0.098),(0.862 ±0.081) were significantly higher than those in normal group(0.381 ±0.068),(0.412 ±0.083);NrF-2, the positive expression rate of Ho-1 in gastric wall invasion degree of T3 +T4 with lymph node metastasis, NTM stage III and IV gastric cancer tissues were significantly increased.The differences were statistically significant ( P <0.05 ) .Conclusion NrF-2 and Ho-1 play the important role in the development of gastric cancer and NrF-2, the positive expression rate of Ho-1 in the gastric carcinoma and gastric wall invasion, lymph node metastasis and NTM staging are closely related.The clinical diagnosis if the combined detection of NrF-2 and Ho-1, is conducive to the early diagnosis of gastric cancer and the prognosis of the disease.
