A network pharmacology study of the association between cigarette toxic components and lung cancer genetic susceptibility
10.3969/j.issn.1005-1678.2016.09.046
- VernacularTitle:基于网络药理学探讨烟毒成分与肺癌易感基因的关系
- Author:
Jie HE
;
Fuhou CHANG
- Publication Type:Journal Article
- Keywords:
network pharmacology;
cigarette toxic component;
lung cancer susceptibility gene
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(9):158-161
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of the main harmful components in cigarette smoke on the expression of lung cancer susceptibility genes by use of the method of network pharmacology, and to explore the correlations of multiple targets and multiple components and diseases.Methods Literatures about the 11 main tobacco toxic ingredients of cigarette smoke were collected from PubMed and the multicomponent-genes-disease network was structured, and then, shared genes which affect the expression of lung cancer susceptibility were screened out.Then use Cytoscape software to construct the multicomponent-shared genes-disease network.Results Network analysis showed that 11 main harmful components in cigarette smoke influnce 106 lung cancer susceptibility genes, 57 lung cancer susceptibility genes of which were affected by at least 2 of the 11 components.Conclusion From the genetic point of view, the relationship of cigarette smoking and lung cancer was elucidated, and the effect of 11 components on the susceptibility genes of other diseases was also explored.This study may provide some statistical references for further detailed research targeting the relationship of cigarette toxic components and lung cancer genetic susceptibility.
