Efficacy evaluation of specific sublingual immunotherapy with standardized dust mites drops on different age patients with allergic rhinitis
10.16066/j.1672-7002.2016.10.001
- VernacularTitle:不同年龄变应性鼻炎患者使用标准化粉尘螨滴剂舌下免疫治疗的疗效评估
- Author:
Liang HAN
;
Yue ZHANG
;
Zhi LI
;
Quanjie YOU
;
Fan YE
;
Qian YIN
;
Jili LIU
- Publication Type:Journal Article
- Keywords:
Rhinitis,Allergic,Perennial;
Rhinitis,Allergic,Seasonal;
Administration,Sublingual;
Immunotherapy;
Dermatophagoides farinae
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2016;23(10):557-560
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To evaluate the difference of efficacy of sublingual immunotherapy on different age patients with allergic rhinitis. METHODS 229 patients with dermatophagoides farina drops allergic rhinitis who have finished SLIT at least 2 years were enrolled and analyzed by retrospective analysis. All patients were divided into different age groups: pre-adolescence(n=107), adolescence(n=53), adulthood(n=69). Indexes for therapeutic effects of SLIT visual analogue scale(VAS) score, rhinitis symptom scores, medication scoreintra- and inter groups were assessed during different stage of treatment(3 months, 1 year and 2 years). Data were analyzed with SPSS 19.0 software. RESULTS Compared with prior treatment, after the SLIT for 3 months, 1 year, 2 years, VAS scores, rhinitis symptom scores, medication scoresof all the patients with allergic rhinitis are significantly decreased; Differences of rhinitis symptom scores(H=0.844, 4.153, 2.669, P>0.05), VAS score(H=1.356, 3.720, 0.313, P >0.05), medication scores(H=1.044, 5.841, 3.399, P>0.05) between groups had no statistical significance at different stage after treatment(3 months, 1 year and 2 years); The differences between 2 years and 1 year of SLIT treatment showed statistical significance in the VAS scores(Z=1.635, P =1.635). CONCLUSION SLIT with dust mites drops had good curative effect and security in patients with allergic rhinitis, which hadno obvious difference between different age groups.
