Short-term clinical efficacy of sublingual immunotherapy in children with allergic rhinitis
10.16066/j.1672-7002.2016.10.002
- VernacularTitle:儿童变应性鼻炎舌下特异性免疫治疗的近期疗效观察
- Author:
Pengpeng WANG
;
Lixing TANG
;
Xiaojian YANG
;
Wentong GE
- Publication Type:Journal Article
- Keywords:
Administration,Sublingual;
Immunotherapy;
Dermatophagoides farinae;
Rhinitis,Allergic,Perennial;
Rhinitis,Allergic,Seasonal;
Eosinophils;
Child
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2016;23(10):561-564
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the short-term clinical efficacy of sublingual immunotherapy in children with allergic rhinitis. METHODS Forty-four patients, from 3-14 years of age, with mite-sensitive allergic rhinitis were treated sublingually with standardized dermatophagoidesfarinae extract. After treatment of 3 or 6 months using the dermatophagoidesfarinae extract, the total nasal symptoms score(including nasal congestion, nasal itching, rhinorrhea and sneezing scores), total rhinitis medicine scores, visual analog scale scores and the percentage of blood eosinophilic granulocyte(Eos%) before and after treatment were evaluated. SPSS 20.0 software was used to analyze the data. RESULTS After 3 or 6 months' treatment,thenasal symptoms score(including nasal congestion, nasal itching, rhinorrhea and sneezing scores), total rhinitis medicine scores and visual analog scale scoreshad significantly reduced,comparing with that before treatment(all P<0.05). The comparison of the total nasal symptoms score(including nasal congestion, rhinorrhea and sneezing scores), total rhinitis medicine scores and visual analog scale scores between 3 months and 6 months treatment had shown no significant difference (all P>0.05), while nasal itching scores had significantly reduced(Z=-4.185, P<0.05). After 6 months' treatment, the percentage of Eos% had significantly reduced compared with that before treatment(Z=-4.544, P<0.05). CONCLUSION SLIT could be an effective treatment in patients with allergic rhinitis sensitive to house dust mite. It would have effect after3 months treatment and Eos%reduced significantly after 6 months treatment.
