Progress in research on the role of microRNA-424 in carcinogenesis and its related mechanism
10.3969.j.issn.1005-4847.2016.05.017
- VernacularTitle:MicroRNA-424在肿瘤发生中的作用和机制研究进展
- Author:
Ping LIU
;
Haiping ZHAO
;
Yumin LUO
- Publication Type:Journal Article
- Keywords:
miR-424;
Neoplasms;
Leukemia
- From:
Acta Laboratorium Animalis Scientia Sinica
2016;24(5):529-534
- CountryChina
- Language:Chinese
-
Abstract:
A member of miR-16 family, miR-424 has been found to be closely related with tumorigenesis, tumor progrssion, prognosis and therapy.This article reviews the expression changes, roles and possible regulating mechanisms of miR-424 in leukemia and various tumors such as breast, cervical, lung, liver and colorectal cancers.Recent studies have demonstrated that the expression of miR-424 is affected by many factors, and miR-424 could be a biomarker of diagnosis, staging and prognosis in cancers,to identify the area of tumor, and be a target of therapy.
