Dual-phase18F-FDG coincidence detection SPECT/CT imaging for differential diagnosis of pulmonary lesions
10.19401/j.cnki.1007-3639.2016.10.010
- VernacularTitle:双时相18F-FDG符合线路SPECT/CT 显像在肺占位性病变鉴别诊断中的应用
- Author:
Yue ZHANG
;
Zuncheng ZHANG
;
Yan JIAO
;
Ping DONG
;
Hua DONG
- Publication Type:Journal Article
- Keywords:
Dual phase;
18F-FDG;
Coincidence Detection;
SPECT/CT;
Lung cancer;
Differential diagnosis
- From:
China Oncology
2016;26(10):866-869
- CountryChina
- Language:Chinese
-
Abstract:
Background and purpose:Although FDG tumor imaging has been applied in clinic widely, dual-phase imaging can provide much more information about the FDG uptaking of pulmonary lesions. The purpose of the study was to evaluate the usefulness of dual-phase18F-FDG coincidence detection SPECT/CT imaging in the differential diagnosis of the pulmonary lesions.Methods:There were 28 patients with pulmonary lesions which were detected by CT. All the patients undertook the SPECT/CT imaging at 2 time-phases respectively: early imaging at 40-60 min and delayed imaging at 2-3 h after the intravenous injection of FDG. Data processing: calculating the radio of T and N in early and delayed imaging respectively; T: The radioactive count of the lesions; N: The radioactive count of the normal tissue; and the change rate:ΔT/N. ROC was used to ifnd out the threshold of T1/N1, T2/N2及ΔT/N in the differential diagnosis between benign and malignant lesions. AUC was used to evaluate the diagnosis value of the dual-phase and single-phase imaging.Results:The threshold of T1/N1 in early imaging was 2.65, whereas AUC was 0.767. The sensitivity, speciifcity and accuracy were 83.3%, 30% and 64.3%, respectively. The threshold of T2/N2 in delayed imaging was 3.14, whereas AUC was 0.847. The sensitivity, speciifcity and accuracy were 94.4%, 60.0% and 82.1%, respectively. The threshold ofΔT/N in delayed imaging was 16.9%, whereas AUC is 0.950. The sensitivity, speciifcity and accuracy were 88.5%, 71.4% and 86.2%, respectively.Conclusion:Dual-phase18F-FDG coincidence detection SPECT/CT imaging has much higher accuracy and speciifcity. However it still has false positivity, and should be analyzed with CT and clinical history.
