The progress of the research on the relationship between stanniocalcins and cancers
10.19401/j.cnki.1007-3639.2016.10.012
- VernacularTitle:斯钙素的生物学特征及其与人体肿瘤关系研究进展
- Author:
Shuwen YANG
;
Ben MA
;
Li ZHOU
;
Yu WANG
- Publication Type:Journal Article
- Keywords:
Stanniocalcin;
Tumor;
Cell proliferation;
Tumor microenvironmemt
- From:
China Oncology
2016;26(10):875-880
- CountryChina
- Language:Chinese
-
Abstract:
Stanniocalcin (STC) was ifrst found as a calcium- and phosphate-regulating hormone produced in bony ifsh by the corpuscles of Stannius. In mammals, the homolog STC-1 displays a relative high amino acid sequence identity (nearly 50%) with ifsh STC, and STC-2 has a lower identity (nearly 35%) with STC-1 and ifsh STC. Both STC-1 and STC-2 are expressed in a variety of tissues. The functions of STC have not been understood. But some ifndings have been reported on their cellular localization, gene structure, and expression in different physiological and pathological conditions, which will be clues in elucidating the functions of STC in mammals. Moreover, STC-1 and STC-2 are expressed in many tumor cell lines, suggesting other biological functions of STC in mammals other than mineral metabolism.
