The research progress of senescence-associated secretory phenotype
10.3969/j.issn.1001-1978.2016.11.006
- VernacularTitle:衰老相关分泌表型的研究进展
- Author:
Huining GUO
;
Shuang LING
;
Jun LIU
;
Yufeng LI
;
Shurong WANG
;
Yanqi DANG
;
Xiaomiao CHEN
;
Jinwen XU
- Publication Type:Journal Article
- Keywords:
cellular senescence;
senescence-associated secreto-ry phenotype;
SASP;
inflammation;
aging mechanism;
age-re-lated diseases
- From:
Chinese Pharmacological Bulletin
2016;32(11):1505-1509
- CountryChina
- Language:Chinese
-
Abstract:
When senescence induction is based on DNA damage, senescent cells display a unique phenotype, which has been termed “senescence-associated secretory phenotype”( SASP ) . SASP, including proinflammatory cytokines, growth factors, chemokines, matrix remodeling enzymes and other cytokines, may be an important driver of chronic inflammation and therefore may be part of a vicious cycle of inflammation, DNA damage and senescence. Senescence-associated secretory products released by such cells can affect the neighboring cells and further exacer-bate their regenerative capacity. SASP is associated with many chronic age-related diseases.
