Research progress in Clostridium difficile tcdC gene
10.7644/j.issn.1674-9960.2016.10.017
- VernacularTitle:艰难梭菌tcdC基因的研究进展
- Author:
Jianxia WANG
;
Hongwei WANG
;
Xiaoyan FENG
;
Dazhi JIN
- Publication Type:Journal Article
- Keywords:
Clostridium difficile;
pathogenicity locus;
tcdC gene;
virulence
- From:
Military Medical Sciences
2016;40(10):847-850
- CountryChina
- Language:Chinese
-
Abstract:
TcdA and B toxins secreted by Clostridium difficile( CD) are two important causes of diseases in organisms. The expression of tcdA and tcdB genes is regulated by a few factors located in the pathogenicity locus ( PaLoc) .Studies have indicated that the tcdC gene is likely to act as a negative regulator of toxin gene expression.So far, it has been debatable whether tcdC gene is regarded as a negative regulator.The mechanism of tcdC gene in pathogenesis remains unclear.In this paper, the structure and function of the tcdC gene are summarized, which will help study the mechanism of tcdC gene and obtain optimal drug targets.
