Recent advances in breast cancer stem cell phenotypes and clinical application
10.19401/j.cnki.1007-3639.2016.08.010
- VernacularTitle:不同表型的乳腺癌干细胞研究现状及其临床应用价值
- Author:
Ning ZHAO
;
Shen FU
- Publication Type:Journal Article
- Keywords:
Breast cancer stem cells;
Stem cell markers;
Molecular isoforms;
Relapse and metastasis
- From:
China Oncology
2016;26(8):699-703
- CountryChina
- Language:Chinese
-
Abstract:
The cancer stem cell theory suggests that cancer develops from a subset of tumor cells that possess characteristics of stem cells. Breast cancer stem cells comprise a sub-population, which possesses the capacity of self-renewal and the potential for differentiation and high tumorigenicity. Evidence from bothin vitro andin vivo studies demonstrates breast cancer stem cells are responsible for tumor relapse, invasion and metastasis, chemo- and radio-resistance and epithelial-mesenchymal transition (EMT). Herein, this review highlighted the recent advances in breast cancer stem cells.
