Mechanisms of loss of immune tolerance in the production of antiplatelet autoantibodies in primary immune thrombocytopenia
10.3760/cma.j.issn.0254-5101.2016.10.014
- VernacularTitle:免疫失耐受在ITP自身抗体产生机制中的研究进展
- Author:
Juping ZHAI
;
Yang HE
;
Binghua YANG
- Publication Type:Journal Article
- Keywords:
ITP;
Autoantibody;
Immune tolerance
- From:
Chinese Journal of Microbiology and Immunology
2016;36(10):790-794
- CountryChina
- Language:Chinese
-
Abstract:
Primary immune thrombocytopenia ( ITP) is an organ-specific autoimmune hemorrhagic disease. The etiology of ITP is still unclear, but loss of immune tolerance to platelet surface antigens is con-sidered as a fundamental cause of ITP. Therapeutic strategies that prevent the activation and proliferation of autoreactive cells have been suggested, which includes clearance of autoreactive cells ( apoptosis) , receptor editing, induction of anergy and extrinsic cellular suppression. Failure at any of these steps may lead to the production of autoantibodies against platelet and megakaryocyte glycoproteins. An improved understanding of the mechanisms for autoantibody production will provide theoretical basis for optimal diagnosis and treatment of ITP.
