Effect of Intralesional Interleukin-2 on Murine Bladder Tumor.
- Author:
Hyeon Hoe KIM
1
;
Eun Sik LEE
;
Sang Jin YOON
;
Moon Ki JO
;
Chongwook LEE
Author Information
1. Seoul National University College of Medicine, Seoul, Korea.
- Publication Type:In Vitro ; Original Article
- Keywords:
bladder tumor;
interleukin-2
- MeSH:
Animals;
Humans;
Injections, Intralesional;
Interleukin-2*;
Mice;
Urinary Bladder Neoplasms*;
Urinary Bladder*
- From:Korean Journal of Urology
1996;37(12):1327-1332
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We tried to evaluate the anticancer effect of intralesional interleukin-2 on murine bladder tumor. MATERIALS AND METHODS: In vitro direct anticancer effect of interleukin-2 upon MBT-2 cells was examined using MTT colorimetric assay in various concentration of human recombinant interleukin-2. Also in vivo study was carried out measuring the tumor implantation rates and growth of the implanted tumors on C3H/He mice receiving six consecutive injections of various concentrations of interleukin-2. RESULTS: No definite direct anticancer effect was found on in vitro study. Also, the tumor implantation rate and growth of the implanted tumors were similar whether interleukin-2's were injected or not. CONCLUSION: Intralesional injection of interleukin-2 does not seem to be effective upon murine bladder tumor.
