Comparison of Anesthetic Effect and Safety of Dexmedetomidine Hydrochloride and Propofol in Painless Colonoscopy
10.6039/j.issn.1001-0408.2016.03.07
- VernacularTitle:盐酸右美托咪定与异丙酚在无痛结肠镜检查中的麻醉效果和安全性比较
- Author:
Jinyan WANG
;
Hui YUE
;
Jinping WANG
- Publication Type:Journal Article
- Keywords:
Dexmedetomidine hydrochloride;
Propofol;
Painless colonoscopy;
Anesthetic effect;
Safety
- From:
China Pharmacy
2016;27(3):308-310
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To compare the anesthetic effect and safety of dexmedetomidine hydrochloride and propofol in pain-less colonoscopy. METHODS:80 patients who underwent painless colonoscopy was retrospectively analyzed and divided into group A and group B. Group A was given loading dose of 1 mg/kg propofol within 30 s and maintained with 6 mg/(kg·h);group B was given loading dose of 0.3 μg/kg Dexmedetomidine hydrochloride injection by micropump for slow pumping 5 min and maintained with 0.2-0.3 μg/(kg·h). Mean arterial pressure(MAP),heart rate(HR),oxygen saturation(SpO2)and respiratory rate(RR)be-fore examination (T0),before microscopic examination (T1),1 min (T2) and 10 min(T3) after microscopic examination,1 min (T4)and 5 min(T5)after colonoscopy withdrawal,onset time of anesthesia,entry time,examination time and discharge time,pa-tients with adjunctive use of fentanyl and incidence of adverse reactions in 2 groups were observed. RESULTS:MAP in group A at T1 was significantly lower than T0,HR in 2 groups at T1-T3 was significantly lower than T0,the differences were statistically signifi-cant(P<0.05),however,there were no significant differences in the SpO2 and RR between 2 groups(P>0.05). Onset time of an-esthesia,patients with adjunctive use of fentanyl and incidence of adverse reactions in group B were significantly lower than group B,the differences were statistically significant(P<0.05). CONCLUSIONS:Both dexmedetomidine hydrochloride and propofol has good anesthetic effect in painless colonoscopy,but dexmedetomidine has better safety.
