Safety Evaluation of Acyclovir in the Treatment of Liver-transplanted Children with EB-viremia
10.6039/j.issn.1001-0408.2016.03.09
- VernacularTitle:阿昔洛韦治疗儿童肝移植受者EB病毒血症的安全性评价
- Author:
Fan CHEN
;
Liqin ZHU
;
Yang LIU
- Publication Type:Journal Article
- Keywords:
Acyclovir;
Liver transplantation;
Children;
EBV-viremia
- From:
China Pharmacy
2016;27(3):313-315
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the safety of acyclovir in the treatment of liver-transplanted children with EB-viremia. METHODS:Retrospectively analysis was conducted for the general information of 10 liver-transplanted children with EB-viremia, preoperative donor and recipient EBV infection and treatment,tacrolimus dose and plasma concentration before and after interven-tion,platelets,serum creatinine and white blood cell levels before and after treatment,and the recurrence were followed-up. RE-SULTS:Biliary atresia was the primary disease for all the children,EB virus polymerase chain reaction(EBV-PCR)was positive, and there was no routine testing for donor HBV infection;6 cases reduced the tacrolimus dose,4 remained unchanged,and 9 cas-es of plasma concentrations reduced after intervention,9 were negative and 2 recoveried. There were no significant differences in the platelets,serum creatinine and white blood cells before and after treatment(P>0.05). CONCLUSIONS:Acyclovir can be used in the treatment of liver-transplanted children with EB-viremia,with good safety.
