Analysis of Clinical Application of Warfarin in Our Hospital
10.6039/j.issn.1001-0408.2016.03.11
- VernacularTitle:我院华法林临床应用分析
- Author:
Bingfa XU
;
Xufang LIN
;
Wei KONG
;
Luyan FAN
- Publication Type:Journal Article
- Keywords:
Warfarin;
Clinical application;
International normalized ratio;
Investigation and analysis;
Pharmaceutical care
- From:
China Pharmacy
2016;27(3):318-320
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the clinical application of warfarin in inpatients of our hospital,and provide reference for standardized application in clinic. METHODS:Totally 267 inpatients records used warfarin in our hospital from Jan. 2013 to Jun. 2014 were investigated to retrospectively analyze the indications,dosage,international normalized ratio(INR)monitoring and bleeding complications of warfarin. RESULTS:Warfarin was mainly used for patients with deep vein thrombosis,cerebral infarc-tion,rheumatic heart disease and pulmonary embolism in our hospital;the dosage of inpatients was in the range of 0.625-6.875 mg with average daily dosage of (2.15 ± 0.72) mg;the INR lower than 1.8 accounted for 52.8%,the INR in the range of 1.8-3.0 (reaching the standard) accounted for 31.8% and INR higher than 3.0 accounted for 15.4%;incidence of adverse reactions was 5.6%,mainly subcutaneous blood spots (petechiae) and urine occult blood,and incidence of severe hemorrhage (intracerebral hemorrhage) was 0.7%. CONCLUSIONS:At present,the clinical application of warfarin is still deficient,and qualified rate of INR is still low. It's important to actively carry out medication intervention and clinical pharmaceutical care.
