Meta-analysis of Xiyanping Combined with Ribavirin in the Treatment of Herpangina in Children
10.6039/j.issn.1001-0408.2016.03.18
- VernacularTitle:喜炎平对比利巴韦林治疗小儿疱疹性咽峡炎的Meta分析
- Author:
Baotao LIAN
;
Zhulin WU
;
Zezhang LI
;
Jiacheng CHEN
;
Xiaoying HU
- Publication Type:Journal Article
- Keywords:
Xiyanping injection;
Ribavirin injection;
Herpangina;
Randomized controlled trial;
Meta-analysis;
Efficacy;
Safe-ty
- From:
China Pharmacy
2016;27(3):337-340
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To systematically review the efficacy and safety of Xiyanping injection versus Ribavirin injection in the treatment of herpangina in children,and provide evidence-based reference for clinical treatment. METHODS:Retrieved from PubMed,Cochrane Library,EMBase,VIP Database,CJFD,Wanfang Database and CBM,randomized controlled trials (RCT) about efficacy and safety of Xiyanping injection versus Ribavirin injection in the treatment of herpangina in children were collected. Meta-analysis was performed by using Rev Man 5.3 software after data extracting and quality evaluating by modified Jadad. RE-SULTS:Totally 14 RCTs were enrolled,involving 1 939 patients. Results of Meta-analysis showed total effective rate [OR=4.69, 95%CI(3.36,6.55),P<0.001],fever clearance time [MD=-1.36,95% CI(-1.60,-1.12),P<0.001],herpes regression time [MD=-1.34,95%CI(-1.61,-1.06),P<0.001],hospitalization time [MD=-1.88,95% CI(-3.68,-0.07),P=0.04] and sali-vation disappearance time [MD=-1.07,95% CI(-1.30,-0.84),P<0.001] of Xiyanping injection were significantly better than Ribavirin injection,there were statistically significant differences. And there was no significant difference in the incidence of ad-verse reactions [OR=0.56,95% CI(0.31,1.03),P=0.06]. CONCLUSIONS:The efficacy of Xiyanping injection is better than Rib-avirin injection in the treatment of herpangina in children,with similar safety.
