Systematic Review of Ginseng Polysacchride Injection Combined with Radiotherapy or Chemotherapy in the Treatment of Malignancies
10.6039/j.issn.1001-0408.2016.03.21
- VernacularTitle:人参多糖注射液联合放化疗用于恶性肿瘤的系统评价
- Author:
Shushan ZHOU
;
Min YANG
;
Yizhen ZHANG
;
Haihua GUO
;
Guohua CHENG
- Publication Type:Journal Article
- Keywords:
Ginseng polysaccharideinjection;
Malignancies;
Meta-analysis;
Efficacy;
Safety
- From:
China Pharmacy
2016;27(3):348-350
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To systematically review the efficacy of Ginseng polysaccharideinjection combined with radiotherapy or chemotherapy in the treatment of malignancies,and provide evidence-based reference for clinical treatment. METHODS:Re-trieved from CNKI,CBM,VIP,Wanfang Database PubMed,EMBase,Web of Science,randomized controlled trials (RCT) about Ginseng polysaccharideinjection combined with radiotherapy or chemotherapy(test group)versus radiotherapy or chemothera-py alone(control group) in the treatment of malignancies were collected. Meta-analysis was performed by using RevMan5.3 soft-ware after data extract and quality evaluation by Cochrane 5.1.0. RESULTS:Totally 7 RCTs were enrolled,involving 567 patients. Results of Meta-analysis showed,the effective rate [OR=1.99,95%CI(1.27,3.14),P=0.003] and improvement rate of life quality [OR=2.95,95%CI(1.75,4.97),P<0.001] in test group were significantly higher than control group,cell abnormal rate [OR=0.26,95%CI(0.16,0.41),P<0.001] was lower than control group,the differences were statistically significant. There were no obvi-ous adverse reaction in 2 groups. CONCLUSIONS:Ginseng polysaccharideinjection combined with radiotherapy or chemotherapy is effective in the treatment of malignancies.
