Comparison and Analysis of Irinotecan Alone or Combined with Xiaoaiping in the Treatment of Elderly Pa-tients with Advanced Gastric Cancer
10.6039/j.issn.1001-0408.2016.05.26
- VernacularTitle:伊立替康单药与联合消癌平治疗老年晚期胃癌的比较研究
- Author:
Yang WU
- Publication Type:Journal Article
- Keywords:
Xiaoaiping injection;
Irinotecan;
Advanced gastric cancer;
Chemotherapy;
Efficacy;
Safety
- From:
China Pharmacy
2016;27(5):657-659
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate therapeutic efficacy and safety of chemotherapy combined with Xiaoaiping injection in the treatment of elderly patients with advanced gastric cancer. METHODS:60 elderly patients with advanced gastric cancer were collected from our department during 2012-2014,and then divided into union group and single group with 30 cases in each group. Single group was given irinotecan(CPT-11)150 mg/m2 added into 0.9%Sodium Chloride injection,and union group was addition-ally given Xiaoaiping injection 80 ml,qd,on the basis of single group. A treatment course lasted for 14 days,and both groups re-ceived 4 courses of treatment. The tumor markers,disease single rate,progression-free survival (PFS) and the incidence of ADR were compared between 2 groups. RESULTS:After treatment,the levels of CEA,CA199 and CA242 in 2 groups were significant-ly lower than before;the union group was significantly lower than the single group,with statistical significance(P<0.05). The dis-ease single rate of union group was 70.00%,which was significantly higher than that of single group (33.33%). PFS of union group was(11.23±2.17)months,which was significantly longer that of single group [(9.36±0.84)months],with statistical signif-icance(P<0.05). The incidence of leucopenia,alanine aminotransferase elevation,diarrhea,stomatitis and hand-foot syndrome in union group was significantly lower than in single group,with statistical significance(P<0.05). CONCLUSIONS:Xiaoaiping in-jection combined with irinotecan chemotherapy for advanced gastric cancer has obvious effect with a low incidence of ADR.
