Effects of CD44 Antigen on Drug Resistance of Breast Cancer Patients
10.6039/j.issn.1001-0408.2016.05.37
- VernacularTitle:CD44抗原对乳腺癌患者耐药性的影响
- Author:
Peizhi LU
;
Huizhang YANG
;
Juan DU
;
Yong JIN
- Publication Type:Journal Article
- Keywords:
CD44;
Breast cancer;
Chemotherapy;
Drug resistance
- From:
China Pharmacy
2016;27(5):686-688
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the effect of CD44 on drug resistance of breast cancer patients. METHODS:62 breast cancer patients were selected,and the expression of CD44 was detected by immunohistochemical method. Drug resistance was eval-uated by WHO criteria,and the expression of CD44 in breast tissue was observed after observation. RESULTS:There were 48 pa-tients sensitive to CD44 and 14 patients with drug resistance,with statistical significance(P<0.05). After chemotherapy,the ex-pression of CD44 in caner tissue was higher than before chemotherapy,that of patients with drug resistance was higher than pa-tients sensitive to CD44,with statistical significance(P<0.01). CONCLUSIONS:CD44 antigen is closely related to chemothera-py resistance of breast cancer,and high expression of CD44 can be used as an important indicator for breast cancer chemotherapy.
