Determination of Release Rate and in vitro Transdermal Rate of Asarinin in Cancer Pain Cataplasm
10.6039/j.issn.1001-0408.2016.04.16
- VernacularTitle:癌痛巴布剂中细辛脂素释放度和离体透皮率的测定
- Author:
Yanping ZHOU
;
Jiao QU
;
Quanwei YANG
;
Hongfeng XU
;
Geng ZHANG
;
Zuowei HU
- Publication Type:Journal Article
- Keywords:
Cancer pain cataplasm;
Asarinin;
Release rate;
in vitro transdermal rate;
HPLC
- From:
China Pharmacy
2016;(4):482-484
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To determinate the release rate and in vitro transdermal rate of asarinin in Cancer pain cataplasm. METHODS:Using homemade devices and modified France diffusion,isolated skin of rats as barrier,normal saline as solvent,the content of asarinin was determined by HPLC. Release rate of Cancer pain cataplasm within 20,50,80 and 120 min and transder-mal amount within 2,4,8,12,24 h were investigated,and accumulative release rate and accumulative transdermal rate were cal-culated. RESULTS:Accumulative release rate by 120 min of asarinin in Cancer pain cataplasm was 73.01%;24 h in vitro transder-mal rate was 26.01%,and transdermal kinetics equation of asarinin was Q=5.717 7t1/2-0.385 4(r=0.979). CONCLUSIONS:Cancer pain cataplasm has good release and transdermal performance. Its transdermal kinetics is in line with Higuchi equation.
