Analysis and Management of Off-label Use of Tamoxifen for Ovulation Induction
10.6039/j.issn.1001-0408.2016.01.40
- VernacularTitle:他莫昔芬超说明书用于促排卵的分析与管理
- Author:
Liu JI
;
Wenhui WU
;
Lili YAN
;
Xiaojun LI
- Publication Type:Journal Article
- Keywords:
Off-label drug use;
Tamoxifen;
Polycystic ovarian syndrome;
Ovulation induction;
Literature analysis;
Standard management
- From:
China Pharmacy
2016;27(1):124-126
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To analyze the rationality of tamoxifen for ovulation induction,and to provide reference for the stan-dardization of off-label use of tamoxifen. METHODS:Takingtamoxifen,ovulation inductionandpolycystic ovarian syn-dromeas keywords,relevant literatures about off-label use of tamoxifen for ovulation induction were analyzed and summarized by a search of CNKI,Wanfang database,PubMed database up to July 2015. RESULTS:58 literatures were searched,among which clinical trial or systematic review about the effect of tamoxifen on ovulation induction were selected. 11 valid literatures were col-lected to confirm clinical efficacy of tamoxifen for ovulation induction. Referring to Diagnosis and Treatment of Polycystic Ovary Syndrome:An Expert Consensus,pharmaceutical affairs council of our hospital had agreed to off-label use of tamoxifen for induc-tion ovulation,and formulated the standard of off-label use of tamoxifen. CONCLUSIONS:Standard management of off-label use of tamoxifen could be better protect the rights both of patient and doctor.
