Effects of Common Percutaneous Enhancers on Transdermal Permeability of Cetirizine Hydrochloride
10.6039/j.issn.1001-0408.2016.01.13
- VernacularTitle:常用透皮吸收促进剂对盐酸西替利嗪经皮渗透性能的影响
- Author:
Haiyan LIU
;
Zhijun HUANG
;
Ying LIANG
;
Xueqin ZHOU
- Publication Type:Journal Article
- Keywords:
Cetirizine hydrochloride;
Transdermal permeability;
Percutaneous enhancers
- From:
China Pharmacy
2016;27(1):41-43
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the effects of common percutaneous enhancers on transdermal permeability of cetirizine hy-drochloride(CET). METHODS:Using pH 7.4 phosphate buffer as receiving solution,accumulative permeation rate as index,mod-ified Franz diffusion cell was used to investigate the effects of common percutaneous enhancers on transdermal permeability of CET in skin of abdomen isolated from mice,such as azone (0.06%-2.5%),oleic acid (0.5%-10%),1,3-propanediol (0.5%-10%),propanetriol(0.5%-5%). RESULTS:1,3- propanediol had no improvement effect on the permeability of CET. 24 h accu-mulative permeation amount of CET in 0.06% azone,0.5% oleic acid and 1% propanetriol were the highest among same types, being 227.94,85.25 and 215.15 μg/cm2,respectively. CONCLUSIONS:Of four percutaneous enhancers,the transdermal enhanc-ing efficiencies from high to low are azone>glycerol>oleic acid>1,3-propanediol. Azone and glycerol have the conspicuous pene-tration enhancing effects.
