Preparation and Characterization of Eugenol-β-cyclodextrin Inclusion Complex
10.6039/j.issn.1001-0408.2016.01.28
- VernacularTitle:丁香酚-β-环糊精包合物的制备与表征
- Author:
Qingying ZHU
;
Yonghui ZHANG
;
Qiong ZHU
;
Le DING
- Publication Type:Journal Article
- Keywords:
Eugenol;
β-cyclodextrin;
Inclusion complex;
Preparation;
Inclusion technology;
Identification;
Characterization
- From:
China Pharmacy
2016;27(1):86-89
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To optimize the inclusion technology of Eugenol-β-cyclodextrin (β-CD) inclusion complex,and to identify and characterize it. METHODS:With the molar ratio of eugenol to β-CD,inclusion temperature and inclusion time as fac-tors,using the yield of inclusion compounds as index,the inclusion technology was optimized by orthogonal test. The formation of inclusion compound was identified by the spectra change of FT-IR,XRD and 1H NMR. Its structure was characterized by 1H RO-ESY NMR. RESULTS:The optimized inclusion conditions were that the molar ratio of eugenol to β-CD was 1.0:1;inclusion tem-perature was 60 ℃;inclusion time was 2.0 h. And the yield of inclusion compound was 73.86%(RSD=0.17%,n=3). 1H NMR results ofβ-CD and its inclusion complex indicated that the optimum qualitative ratio of the inclusion complex was 1.0:1. The inter-molecular interaction between eugenol and β-CD was confirmed by the spectrum analysis of FT-IR and XRD. 1H ROESY NMR re-sults indicated the structure of inclusion complex mainly was that the phenyl of eugenol was in the cavity of β-CD,the vinyl was outside. CONCLUSIONS:The inclusion technology is reasonable and feasible,and can be used for the inclusion of eugenol andβ-CD. The formation of inclusion compound is confirmed by the spectrum analysis.
