Preparation of Dexibuprofen Sustained-release Pellets and Analysis on Drug Release Behavior

VernacularTitle:右旋布洛芬缓释微丸的制备及其释药行为分析
Author: Haigang LI ; Xiang CHEN ; Shaofen GUO ; Chaohui GE
Publication Type:Journal Article
Keywords: Dexibuprofen; Sustained-release pellets; Centrifugal granulation; Eudragit; Drug release in vitro
From: China Pharmacy 2016;27(1):95-97
CountryChina
Language:Chinese
Abstract: OBJECTIVE:To prepare dexibuprofen sustained-release pellets,and to analyze the drug release behavior in vitro. METHODS:Centrifugal granulation powder layering-eudragit dispersion coating method was used to prepare dexibuprofen sus-tained-release pellets using 3%HPMC as adhesive agent. The formula of the pellets was optimized by orthogonal test with weight ra-tio of sucrose to dexibuprofen,weight ratio of HPMC to Eudragit NE30D and coating weight as factors,using 1,4 and 10 h accu-mulated release rate (Q) as index. The release of the drug from the pellets was analyzed. RESULTS:The optimized formulation was that the proportion of sucrose to drug was 1:10,the weight ratio of HPMC to Eudragit NE30D was 1.5:1,the increased weight of coating material was 8%. Q1 h,Q4 h and Q10 h of prepared pellets were 21%,57% and 89%,respectively(n=3). The co-rrelation coefficient of zero-order,one-order and Higuchi equation release model were 0.956 6,0.989 9,0.996 5. CONCLUSIONS:Prepared pellets show good sustained-release effect in vitro. Drug release of pellets is more in accordance with Higuchi equation.