Optimization of the Enhancers for Euodia rutaecarpa Superfines Cataplasm
10.6039/j.issn.1001-0408.2016.01.16
- VernacularTitle:吴茱萸超微粉巴布剂促渗剂的优选
- Author:
Weimiao WU
;
Jingying LUO
- Publication Type:Journal Article
- Keywords:
Euodia rutaecarpa;
Evodiamine;
Rutaecarpin;
Superfines cataplasm;
Enhancer
- From:
China Pharmacy
2016;27(1):50-53
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate penetrative effects of a penetration enhancer and multiple penetration enhancers combi-nation with different proportions on Euodia rutaecarpa superfines cataplasm,so as to optimize enhancer and their concentrations. METHODS:Modified Franz diffusion cell was employed with isolated mice abdominal skin as barrier. HPLC method was adopted to detect the effects of a penetration enhancer (propanediol, azone, oleic acid), multiple penetration enhancers (propanedi-ol-azone,propanediol-oleic acid,propanediol-azone-oleic acid),their proportion and amount on accumulative permeation quantity (Qn) of evodiamine and rutaecarpin in Euodia rutaecarpa superfines cataplasm. RESULTS:The penetrative effect of a penetration enhancer propanediol was significantly better than that of other one penetration enhancers and multiple penetration enhancers;the higher proportion of propanediol in multiple penetration enhancer system was,the better penetrative effects of evodiamine and rutae-carpin had. Using 3%,5 % and 7 % propanediol as enhancer,Q36 h of evodiamine were 11.290,14.332 and 13.537 μg/cm2,and those of rutaecarpin were 11.965,14.856 and 13.901 μg/cm2. CONCLUSIONS:The penetrative effect of 5% propanediol is the best,and can be used as enhancer for E. rutaecarpa superfines cataplasm.
