Stability Study of Tramadol,Fentanyl and Ondansetron Combined with 0.9% Sodium Chloride Injection in Analgesia Pump

VernacularTitle:曲马多、芬太尼、昂丹司琼与0.9％氯化钠注射液在镇痛泵中的配伍稳定性考察
Author: Wen CHEN ; Baoxia FANG ; Huimin LIU ; Fuchao CHEN ; Jun ZHU
Publication Type:Journal Article
Keywords: Tramadol; Fentanyl; Ondansetron; Compatibility; Stability; HPLC
From: China Pharmacy 2016;27(8):1048-1050
CountryChina
Language:Chinese
Abstract: OBJECTIVE:To study the stability of Tramadol hydrochloride,Fentanyl citrate and Ondansetron hydrochloride in-jection in 0.9% Sodium chloride injection. METHODS:At room temperature [(25±1)℃],three injections were poured into infu-sion bag of disposable analgesia pump,and diluted with 0.9% Sodium chloride injection. The changes in precipitation,turbidity, color and pH value of the mixture were observed. The relative percentage of three injections within 72 h were determined by HPLC method. RESULTS:There was no significant change in the pH value and appearance of the mixture. Relative percentage of tramad-ol hydrochloride,fentanyl citrate and ondansetron hydrochloride were all higher than 97% within 72 h. CONCLUSIONS:The mix-ture of Tramadol hydrochloride,Fentanyl citrate and Ondansetron hydrochloride injection in 0.9% Sodium chloride injection keep stable within 72 h under room temperature.