Analysis of Drug Resistance Characteristics of Imipenem-resistant Pseudomonas aeruginosa and Infection Risk Factors in Zhoushan Area
10.6039/j.issn.1001-0408.2016.08.16
- VernacularTitle:舟山地区耐亚胺培南铜绿假单胞菌耐药特征及感染危险因素分析
- Author:
Chunlei SUN
;
Chaohui GAN
;
Baofeng YAO
- Publication Type:Journal Article
- Keywords:
Imipenem;
Pseudomonas aeruginosa;
Drug resistance;
Carbapenemases;
Gene diversity;
Risk factor
- From:
China Pharmacy
2016;27(8):1061-1063
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To provide reference for imipenem-resistant Pseudomonas aeruginosa infection control. METHODS:114 patients infected with imipenem-resistant P. aeruginosa were selected from 3 tertiary hospitals in Zhoushan during Feb. 2013 to Feb. 2014. 114 strains of P. aeruginosa were isolated from clinical specimens,and drug resistance characteristics and carbapene-mase-producing gene diversity were analyzed. 101 inpatients with imipenem-resistant P. aeruginosa infection were included in con-trol group;univariate and multivariate Logistic regression analysis were adopted to explore the risk factors of imipenem-resistant P. aeruginosa infection. RESULTS:114 strains were sensitive to polymyxin B,and had different levels of resistance to other 9 kinds of antibiotics. Carbapenemase-producing gene were mainly IMP and VIM type gene. Long-term hospitalization,mechanical ventila-tion,used imipenem and early combined use of antibiotics were risk factors of imipenem-resistant P. aeruginosa infection. CON-CLUSIONS:In Zhoushan area,imipenem-resistant P. aeruginosa shows serious drug resistance. To avoid long-term hospitalization and early combined use of antibiotics can reduce imipenem-resistant P. aeruginosa infection.
