Effect of Nifedipine Combined with Losartan on the Blood Pressure and Renal Function of Hypertension Complicated with Coronary Heart Disease
10.6039/j.issn.1001-0408.2015.36.20
- VernacularTitle:硝苯地平联合氯沙坦对高血压合并冠心病患者血压和肾功能的影响
- Author:
Chao WU
;
Yimin WANG
;
Lijuan WU
;
Chun FAN
;
Feng HU
- Publication Type:Journal Article
- Keywords:
Nifedipine;
Losartan;
Hypertension;
Coronary heart disease;
Renal functions
- From:
China Pharmacy
2015;26(36):5097-5099
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the effect of nifedipine combined with losartan on the blood pressure and renal function of hypertension complicated with coronary heart disease. METHODS:150 patients with hypertension complicated with coronary heart disease were randomly divided into observation group and control group. Control group was orally treated with Nifedipine sustained release tablet 30 mg,once a day;observation group was additionally treated with Losartan potassium capsules 50 mg,once a day. The treatment course for both groups was 1 month. Systolic blood pressure,diastolic blood pressure,renal function indicators be-fore and after treatment,and incidence of adverse reactions in 2 groups were observed. RESULTS:After treatment,systolic blood pressure and diastolic blood pressure after 3 months was lower than 1 month and lower than before treatment in same group,renal function indicators were significantly lower than before treatment,and observation group was lower than control group,the differ-ences were statistically significant(P<0.05);the incidence of adverse reactions in observation group was significantly lower than control group,the difference was statistically significant(P<0.05). CONCLUSIONS:Nifedipine combined with losartan can well control the blood pressure of hypertension complicated with coronary heart disease,protect renal functions,with good safety.
