Cross-sectional Survey on the Drug Off-label Use in A Primary Hospital

VernacularTitle:某基层医院超说明书用药情况的横断面调查
Author: Lihua WANG
Publication Type:Journal Article
Keywords: Primary hospital; Drug package inserts; Drug off-label use; Cross-sectional survey
From: China Pharmacy 2015;26(36):5107-5109
CountryChina
Language:Chinese
Abstract: OBJECTIVE:To provide reference for the clinical rational drug use. METHODS:Cross-sectional survey was adopt-ed to statistically analyze the off-label use of inpatient(489 prescriptions)and outpatient prescriptions(466 prescriptions)in our hos-pital in Jun. 19,2014. RESULTS:The prescription items and ratios of off-label use in inpatients and outpatients in our hospital were 240,14.1%(240/1 704)and 149,17.4%(149/852),respectively. The top 4 types of drug off-label use included changing ad-ministration frequency,indications,compatibility concentrations of injections and dosage. CONCLUSIONS:Some of off-label use are rational,supporting by kinds of guidelines,expert consensus and literature reporting;while some are irrational,clinic should avoid this kind of irrational use and be strictly controlled by pharmacists. Meanwhile,it is suggested that the drug manufacturers up-date the instructions timely to provide reference for ensuring safety drug use of patients.