Efficacy and Safety of Calf Spleen Extract Injection Combined with Chemotherapy in the Treatment of Can-cer:A Meta-analysis
10.6039/j.issn.1001-0408.2015.36.28
- VernacularTitle:小牛脾提取物注射液辅助化疗治疗肿瘤疗效与安全性的Meta分析
- Author:
Yuxia BAI
;
Sheng HAN
;
Wensheng LI
;
Luwen SHI
- Publication Type:Journal Article
- Keywords:
Calf spleen extraction injection;
Cancer;
Chemotherapy;
Systematical review;
Efficacy;
Safety
- From:
China Pharmacy
2015;26(36):5119-5122
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To systematically review the efficacy and safety of Calf spleen extract injection combined with chemo-therapy in the treatment of cancer,and provide evidence-based reference for clinical treatment. METHODS:Retrieved from Co-chrane Library,PubMed,Medline,EMBase,CJFD,Wanfang and VIP Database,randomized controlled trials(RCT)of the effica-cy and safety about Calf spleen extract injection combined with chemotherapy in the treatment of cancer were collected. Meta-analy-sis was performed by using Rev Man 5.0 software after data extract and quality evaluation by Cochrane 5.0. RESULTS:Totally 23 RCT were enrolled,including 1 682 patients. Results of Meta-analysis showed Calf spleen extract injection combined with chemo-therapy in the treatment of cancer can significantly improve the effective rate [OR=2.17,95%CI(1.68,2.81),P<0.001] and im-provement rate of life quality [OR=4.26,95%CI(2.47,7.32),P<0.001] and also reduce the degree rate of WBC and PLT,the inci-dence rate of nausea and emesis,the differences were statistically significant. CONCLUSIONS:Calf spleen extraction injection combined with chemotherapy has good efficacy and safety in the treatment of cancer.
