Association of CYP3A5 and IL-10 Polymorphisms with the Individual Dosage Regimen of Tacrolimus in Lung Transplantation Recipients
10.6039/j.issn.1001-0408.2015.35.12
- VernacularTitle:肺移植术后受体CYP3A5和白介素-10基因多态性与他克莫司个体化用药的关系
- Author:
Wen XU
;
Xiaoqing ZHANG
;
Junwei FAN
;
Yuping LI
;
Boxiong XIE
;
Ping SHU
- Publication Type:Journal Article
- Keywords:
Lung transplantation;
Tacrolimus;
Cytochrome P4503A family polypeptide 5;
IL-10;
Polymorphism
- From:
China Pharmacy
2015;26(35):4931-4934
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the association of Cytochrome P4503A family polypeptide 5 [(CYP)3A5] and IL-10 poly-morphisms with the concentration/dose(C/D) ratio of tacrolimus in lung transplantation recipients. METHODS:CYP3A5 polymor-phisms at rs774746 and IL-10 polymorphisms at rs1800896 from peripheral blood cell of 51 lung transplant recipients was detected by Se-quenom MassArray iPLEX GOLD system. The relationship between gene polymorphism and tacrolimus C/D ratio was analyzed. RE-SULTS:The tacrolimus C/D ratio of the recipients who carried CYP3A5 rs776746 GG genotype were higher than those with AA+GG genotype,with statistical significance(P<0.01). The tacrolimus C/D ratio of the recipients who carried IL-10 rs1800896 AA genotype were higher than those with AG genotype during 1 week and 2 weeks after transplantation,with statistical significance(P<0.05). Com-bined analysis of these two genes,the tacrolimus C/D ratio of the recipients who carried more fast metabolic alleles were higher than those who didn't carry fast metabolic alleles,with statistical significance(P<0.01). CONCLUSIONS:Determination of recipients CYP3A5 at rs 776746and IL-10 at rs800896 genotype may be performed prospectively to help individualizing tacrolimus dose regimen.
