Clinical Observation of Tripterygium Glycosides Combined with Valsartan in the Treatment of Idiopathic Membranous Nephropathy
10.6039/j.issn.1001-0408.2015.35.35
- VernacularTitle:雷公藤多苷联合缬沙坦治疗特发性膜性肾病的临床观察
- Author:
Li LING
;
Ge WEI
;
Li CHEN
;
Zhaoli XIE
- Publication Type:Journal Article
- Keywords:
Tripterygium glycosides;
Valsartan;
Drug combination;
Idiopathic membranous nephropathy;
Immunosuppressive therapy
- From:
China Pharmacy
2015;26(35):4997-4999
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe therapeutic efficacy and safety of tripterygium glycosides combined with valsartan in the treatment of idiopathic membranous nephropathy(IMN). METHODS:A total of 85 patients with IMN were enrolled and randomly divided into observation group(42 cases)and control group(43 cases). Based on routine treatment(reducing lipid,anti-platelet ag-gregation,protein dietary restriction),control group was additionally given oral valsartan,with initial dose of 80 mg/d,and gradu-ally adding the amount to 160 mg/d if there was no obvious ADR;based on control group,observation group was additionally giv-en Tripterygium glycosides tablet 40 mg,tid,and reducing the amount to 20 mg,tid after complete remission. 2 groups were treat-ed for 12 months. RESULTS:Total effective rate of observation group was 92.86%,which was significantly higher than that of con-trol group(74.42%),with statistical significance(P<0.05). Compared with before treatment,the levels of 24 h urine protein,TC and TG of 2 groups were decreased after treatment,and serum albumin(ALB)of observation group increased;24 h urine protein and TG of observation group was lower than control group,while the serum level of ALB was higher than control group,with sta-tistical significance(P<0.05 or P<0.01). No obvious ADR was found in 2 groups. CONCLUSIONS:Tripterygium glycosides com-bined with valsartan can improve the kidney function and blood lipid level of IMN patients with high safety.
