Correlation Analysis of the Patients with End Stage Renal Disease and Antibiotics Encephalopathy after Giv-ing Ceftazidime
10.6039/j.issn.1001-0408.2015.36.14
- VernacularTitle:终末期肾脏病患者应用头孢他啶后并发抗生素脑病的相关性分析
- Author:
Changhua GONG
;
Shuwei YE
- Publication Type:Journal Article
- Keywords:
Hemodialysis;
End stage renal disease;
Antibiotic encephalopathy;
Ceftazidime;
Correlation
- From:
China Pharmacy
2015;26(36):5083-5084
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the correlation of patients with end stage renal disease(ESRD)and antibiotics encepha-lopathy after giving ceftazidime. METHODS:Data of 20 ESRD patients with antibiotics encephalopathy were retrospectively ana-lyzed and included into observation group,and also 20 ESRD patients with no antibiotics encephalopathy were included into con-trol group. Patients with no improved conditions in observation group were given hemodialysis associated with hemoperfusion after 2-5 days of ceftazidime withdrawal. The hemoglobin(Hb),albumin(Alb),serum creatinine(Scr),blood urea nitrogen(BUN), total cholesterol(TC),triglyceride(TG),parathyroid hormone(PTH),use time and cumulative dose of ceftazidime in observa-tion group were detected and compared with control group. RESULTS:The age,use time and cumulative dose of ceftazidime in ob-servation group were significantly higher than control group,Alb level was lower than control group,the differences were statisti-cally significant(P<0.05). 19 patients in remission and 1 died in observation group. CONCLUSIONS:The antibiotic encephalopa-thy in ESRD patients has correlation with elderly,hypoalbuminemia,use time and cumulative dose of ceftazidime.
