Clinical Observation of Mecobalamin Combined with Folic Acid in the Treatment of Diabetic Peripheral Neu-ropathy with Hyperhomocysteinemia
10.6039/j.issn.1001-0408.2015.36.16
- VernacularTitle:甲钴胺联合叶酸治疗糖尿病周围神经病变合并高同型半胱氨酸血症的临床观察
- Author:
Hongling YAN
;
Aihua ZHANG
;
Huiqiong LI
;
Xiongbing CHEN
;
Shengqun ZHU
;
Jieqiang CHEN
;
Liping SUN
- Publication Type:Journal Article
- Keywords:
Mecobalamin;
Folic acid;
Diabetic peripheral neuropathy;
Homocysteine;
Efficacy;
Safety
- From:
China Pharmacy
2015;26(36):5087-5089
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the efficacy and safety of mecobalamin combined with folic acid in the treatment of dia-betic peripheral neuropathy(DPN)with hyperhomocysteinemia. METHODS:Data of 40 DPN patients with high hyperhomocystein-emia were enrolled into high Hcy group and 30 DPN patients with normal Hcy were enrolled into normal Hcy group. Normal Hcy group was given diet control,hypoglycemic drugs or insulin for controlling glucose and other conventional treatment to make the fasting plasma glucose was lower than 7.0 mmol/L and 2 h postprandial glucose lower than 11.0 mmol/L;based on it,high Hcy group was given Mecobalamin injection 500 μg by intramuscular injection,once a day+Folic acid tablet 5 mg,once a day. 14 d was a treatment course and it lasted 2 courses. Clinical efficacy,Hcy level,the motor nerve conduction velocity(MNCV)and sen-sory nerve conduction velocity (SNCV) of tibial and peroneal nerve and total symptom scale (TSS) score before and after treat-ment in high Hcy group were observed and compared with normal Hcy group,and the incidence of adverse reactions in high Hcy group was recorded. RESULTS:After treatment,the total effective rate in high Hcy group was 75.0%;Hcy and TSS score in high Hcy group were significantly lower than before and higher than normal Hcy group,MNCV and SNCV of tibial and peroneal nerve were significantly higher than before and lower than normal Hcy group,the differences were statistically significant(P<0.05). Th incidence of adverse reactions of high Hcy group was 5.0%. CONCLUSIONS:Based on the conventional treatment,Mecobalamin combined with folic acid has good efficacy in the treatmen of DPN with hyperhomocysteinemia,it can significantly reduce plasma Hcy levels and improve nerve conduction velocity in patients with DPN,with good safety.
