Clinical Observation of Proton Pump Inhibitors Combined with Compound Digestive Enzyme Tablet in the Treatment of Functional Dyspepsia of Epigastric Pain Syndrome with Abdominal Distension
10.6039/j.issn.1001-0408.2016.12.08
- VernacularTitle:质子泵抑制剂联合复方消化酶片治疗伴腹胀的上腹痛综合征型功能性消化不良的临床观察
- Author:
Pengli GUO
;
Sai GU
- Publication Type:Journal Article
- Keywords:
Functional dyspepsia;
Compound digestive enzyme tablets;
Proton pump inhibitors;
Efficacy;
Safety
- From:
China Pharmacy
2016;27(12):1608-1610
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the efficacy and safety of proton pump inhibitors combined with Compound digestive en-zyme tablet in the treatment of epigastric pain syndrome with abdominal distension. METHODS:156 patients with epigastric pain syndrome with abdominal distension were randomly divided into control group(75 cases)and observation group(81 cases). Con-trol group was given 40 mg Esomeprazole enteric-coated tablet for once half an hour before breakfast;observation group was addi-tionally given 243.6 mg Compound digestive enzyme tablet immediately after meal,3 times a day. The treatment course for both groups was 2 weeks. Clinical efficacy,clinical symptom score,pepsinogenⅠ(PGⅠ),pepsinogenⅡ(PGⅡ),2,4 h postprandial gastric emptying rate before and after treatment,and incidence of adverse reactions in 2 groups were observed. RESULTS:The to-tal effective rate in observation group was significantly higher than control group,the difference was statistically significant (P<0.05). There was no significant difference in the incidence of adverse reactions between 2 groups (P>0.05). Before treatment, there were no significant differences in the clinical symptom score,PGⅠ,PGⅡand 2,4 h postprandial gastric emptying rate(P>0.05). After treatment,clinical symptom score in 2 groups were significantly lower than before,and observation group was lower than control group;PGⅠ and PGⅡ in observation group were significantly higher than before and control group,the differences were statistically significant(P<0.05);and there were no significant differences in the 2,4 h postprandial gastric emptying rate be-tween 2 groups and PGⅠ and PGⅡ in control group before and after treatment(P>0.05). CONCLUSIONS:The efficacy of pro-ton pump inhibitors combined with Compound digestive enzyme tablet is superior to the proton pump inhibitors in the treatment of epigastric pain syndrome with abdominal distension,with similar safety.
