Effects of Atorvastatin Combined with Allopurinol on Blood Lipid and Blood Uric Acid in Patients with Hy-perlipidemia and Hyperuricemia
10.6039/j.issn.1001-0408.2016.12.17
- VernacularTitle:阿托伐他汀联合别嘌醇对高脂血症合并高尿酸血症患者血脂、血尿酸的影响
- Author:
Qinxuan LU
;
Weihong MEI
- Publication Type:Journal Article
- Keywords:
Atorvastatin;
Allopurinol;
Hyperlipoidemia and Hyperuricemia;
Blood lipid;
Blood uric acid
- From:
China Pharmacy
2016;27(12):1632-1634
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the effects of atorvastatin combined with allopurinol on blood lipid and blood uric acid in patients with hyperlipidemia and hyperuricemia. METHODS:90 patients with hyperlipidemia and hyperuricemia were randomly di-vided into group A,group B and group C. Group A was orally given 0.1 g Allopurinol tablet,once a day+30 mg Atorvastatin calci-um tablet,once a day. Group B was given Atorvastatin calcium tablet(the same dose with group A). Group C was given Allopuri-nol tablet (the same dose with group A). The treatment course for all groups was 4 weeks. TG,TC,LDL,HDL,UA,BUN, ALT and CK before and after treatment,and incidence of adverse reactions in all groups were observed. RESULTS:After treat-ment,TG,TC and LDL in all groups were significantly lower than before,group A and B were lower than group C,the differenc-es were statistically significant (P<0.05);UA in all groups was significantly lower than before,group A and B were lower than group C,group A was lower than group B,the differences were statistically significant(P<0.05);ALT in group A and B,CK in all groups and BUN levels in group A and group C were significantly higher than before,CK in group A and group B higher than group C,group A was higher than group B,the differences were statistically significant(P<0.05). And there was no significant dif-ference in the incidence of adverse reactions among all groups(P>0.05). CONCLUSIONS:Atorvastatin combined with allopurinol can significantly reduce the blood lipid and blood uric acid levels of patients,with good safety.
