Kanglaite Injection Combined with Radiothreapy in the Treatment of Non-small Cell Lung Cancer:A System-aic Review
10.6039/j.issn.1001-0408.2016.12.18
- VernacularTitle:康莱特注射液联合放疗用于非小细胞肺癌的系统评价
- Author:
Baotao LIAN
;
Chaoyuan HUANG
;
Zhenjie ZHUANG
;
Liu LIAO
;
Yang CAO
- Publication Type:Journal Article
- Keywords:
Kanglaite injection;
Radiothreapy;
Non-small cell lung cancer;
Systematic review;
Efficacy;
Safety
- From:
China Pharmacy
2016;27(12):1634-1637
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To systematically review the efficacy and safety of Kanglaite injection combined with radiothreapy in the treatment of the non-small cell lung cancer (NSCLC),and provide evidence-based reference for clinical treatment. METH-ODS:Retrieved from PubMed,Cochrane Library,EMBase,VIP,CJFD,Wanfang database and CBM,randomized controlled tri-als(RCT)about the efficacy and safety of Kanglaite injection combined with radiothreapy in the treatment of NSCLC were collect-ed. Meta-analysis was performed by using Rev Man 5.3 software after data extraction and quality evaluation with modified Jadad scale. RESULTS:Totally 9 RCTs were included,involving 561 patients. Results of Meta-analysis showed,Kanglaite injection com-bined with radiothreapy can significantly improve the effective rate [OR=2.99,95%CI(2.07,4.31),P<0.001] and improvement rate of life quality [OR=3.74,95%CI(2.36,5.92),P<0.001],and reduce the incidence of radiation pneumonitis [OR=0.23,95%CI (0.12,0.47),P<0.001] and radiation esophagitis [OR=0.10,95%CI(0.05,0.21),P<0.001] of NSCLC patients,the differences were statistically significant. CONCLUSIONS:Both the efficacy and safety of Kanglaite injection combined with radiothreapy in the treatment of NSCLC are superior to radiothreapy alone.
