Effect of Compound Pueraria Tablets on Osteoprosis Model Rats Induced by Retinoic Acid
10.6039/j.issn.1001-0408.2015.34.17
- VernacularTitle:复方葛根片对维甲酸诱导骨质疏松模型大鼠的治疗作用
- Author:
Qikang LU
;
Zhengwei GU
;
Yunsheng BI
;
Shuyu ZHANG
;
Wenchao YANG
;
Yanli YU
- Publication Type:Journal Article
- Keywords:
Compound pueraria tablets;
Retinoic acid;
Osteoporosis model;
Rat;
Bone density
- From:
China Pharmacy
2015;(34):4804-4806
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the effect of Compound pueraria tablets on osteoporosis model rats induced by retinoic acid. METHODS:The osteoporosis model was induced by intragastric administration of retinoic acid solution for 15 days;normal group was established. After modeling,the rats were randomly divided into model control group,Xianling gubao capsule [0.32 g/(kg·d)] positive control group,Compound pueraria tablets low-dose and high-dose [0.24,0.4 g/(kg·d)] groups (n=8). After 6 weeks of ig,the serum sample was collected to determine the levels of serum calcium(s-Ca),serum phosphorus(s-P),ALP and bone gla protein (BGP);bone density instrument was used to detect the contents of bone mineral density (BMD),bone mineral content (BMC),bone image area (BIA) and muscle content (MC);the results of compact bone substance scanning were observed. RE-SULTS:Compared with normal group,the levels of s-Ca,BMD,BMC and MC in rats were decreased in model control group, while the level of BGP was increased(P<0.05 or P<0.01). Compared with model control group,related index and compact bone substance scanning of Compound pueraria tablets groups were all improved;the levels of s-Ca,s-P,ALP,BMD and MC were in-creased in Compound pueraria tablets high-dose group,while the level of BGP was decreased;the levels of BMD and MC were in-creased significantly in Compound pueraria tablets low-dose group(P<0.05 or P<0.01). CONCLUSIONS:Compound pueraria tab-lets can improve the osteoporosis induced by retinoic acid in rats.
